Deaths from self-poisoning with temazepam by yourself or in combination with other substances were proven to get extra typical than with some other benzodiazepines except flurazepam, which experienced the very best mortality price for each million prescriptions.
The Poison Management Centre could be contacted for support in intricate poisoning scenarios.[65] The sedative results of temazepam can be counteracted by flumazenil—a nonspecific competitive antagonist on the benzodiazepine receptor.[sixty six]
Temazepam, like other benzodiazepine medication, could potentially cause Bodily dependence and dependancy. Withdrawal from temazepam or other benzodiazepines right after normal use normally contributes to benzodiazepine withdrawal syndrome, which resembles signs and symptoms through alcohol and barbiturate withdrawal. The upper the dose and the extended the drug is taken, the higher the potential risk of experiencing unpleasant withdrawal signs. Withdrawal signs may occur from normal dosages and immediately after short-expression use. Abrupt withdrawal from therapeutic doses of temazepam right after extensive-term use might end in a intense benzodiazepine withdrawal syndrome.
Like all benzodiazepines, the use of this drug in combination with Liquor potentiates the Unwanted side effects, and can cause toxicity and Demise.
Partial but incomplete tolerance develops to those impairments.[23] The smallest feasible effective dose really should be Utilized in elderly or pretty sick sufferers, as being a possibility of apnea and/or cardiac arrest exists. This chance is elevated when temazepam is presented concomitantly with other prescription drugs that depress the central nervous procedure (CNS).[24]
The quantity of drugs that you just consider depends on the strength on the medicine. Also, the quantity of doses you take on a daily basis, time allowed among doses, and also the period of time you go ahead and take medication count on the clinical trouble for which that you are utilizing the medication.
When you find yourself having this medication, it is especially essential that your Health care Skilled know Should you be using any from the medicines outlined underneath. The following interactions happen to be picked on The premise of their potential significance and they are not automatically all-inclusive.
This might not be an entire listing of medicines that may connect with temazepam. Usually Look at with all your healthcare supplier.
Sure medicines should not be utilised at or within the time of ingesting food stuff or consuming specific sorts of food given that interactions may well manifest.
Whilst certain medicines shouldn't be utilised alongside one another in the least, in other cases two distinct medicines may very well be applied with each other regardless of whether an conversation could come about. In these cases, your medical doctor will want to change the dose, or other precautions might be necessary.
A 1995 Australian analyze of individuals admitted to medical center after benzodiazepine overdose corroborated these temazepam kopen outcomes, and found temazepam overdose way more prone to produce coma than other benzodiazepines (odds ratio one.86). The authors famous numerous variables, for example differences in potency, receptor affinity, and fee of absorption concerning benzodiazepines, could clarify this better toxicity.
Verify with all your overall health treatment professional if any of the subsequent Negative effects go on or are bothersome or In case you have any questions on them:
Benzodiazepines are commonly detected by customs at various ports and airports, arriving by mail, also identified at times inside the baggage of air travellers, typically smaller or medium quantities (around 200–300 tablets) for personal use.
Making use of this medicine with any of the subsequent might lead to an elevated risk of specific Uncomfortable side effects but could be unavoidable sometimes. If made use of together, your medical doctor may well alter the dose or how often you employ this medication, or Supply you with Distinctive Guidelines about the usage of foodstuff, Liquor, or tobacco.